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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Neuropharmacology. 2019 Jun 19;158:107677. doi: 10.1016/j.neuropharm.2019.107677

Figure 2.

Figure 2

Mean (±SEM) changes in temperature, temperature differentials, and locomotion induced by iv administration of midazolam (A-C) and heroin injected one hour after saline (D-F) or midazolam pretreatment (G-I). Filled symbols indicate values significantly different from pre-injection baseline (time=0), shown as black horizontal dotted lines. Vertical black lines indicate the moment of injection. Red dotted line (G) shows the pre-heroin baseline established after midazolam injection. Horizontal dotted lines in the locomotion graphs show mean locomotion for 10 min preceding drug injection.