Summary of analysis of sex and ancestry effects on points of departure (PODs), based on linear mixed effect modeling. (A) Box plots showing the percent contribution of ancestry and sex across chemicals for the phenotypes Beats per Minute and Decay/Rise ratio. (B) – (D) Summary of contribution of ancestry, sex, and other to variation in PODs for three compounds: bepridil (B), acenaphthene (C), and titanocene (D). Included are the percent contributions to variations, and boxplots of PODs grouped by ancestry (Other; H/L, Hispanic/Latino; W/NH, White/non-Hispanic; As, Asian, B/AA, Black/African American), and by sex (M, male; F, female). See Supplemental Fig. 6 for complete analysis of all compounds.