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. Author manuscript; available in PMC: 2020 Jul 4.
Published in final edited form as: Adv Drug Deliv Rev. 2019 Jul 4;144:35–56. doi: 10.1016/j.addr.2019.07.002

Figure 4.

Figure 4.

(a) Quantification of cleaved-caspase 3 (CC3) staining in tumor sections of mice treated with various nanoparticles with or without IR compared to no treatment control. Adapted with permission from [111]. (b) Tumor sections stained with CC3 for (i) empty micelle, (ii) dual-loaded micelle, (iii) empty micelle + IR, and (iv) dual-loaded micelle + IR. Inset sections represent the corresponding boxed region in whole-tumor image. Outlined sections are designed to illustrate the extent of CC3 staining and thus apoptosis. Adapted with permission from [112].