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. Author manuscript; available in PMC: 2020 Jul 4.
Published in final edited form as: Adv Drug Deliv Rev. 2019 Jul 4;144:35–56. doi: 10.1016/j.addr.2019.07.002

Figure 5.

Figure 5.

Radiation influences the tumor microenvironment in many ways and recently research has begun to further understand these effects and the complex way they may be exploited to enhanced tumoral accumulation of nanoparticles. (a) Graphical abstract highlights some of these influences. Adapted with permission from [135]. (b) (top) Pretreatment with radiation decreased IFP 24 h post-treatment and the intratumoral bulk accumulation in MDA-MB-231 tumors. (bottom) Tumor IFP was low (4.5 ± 1.5 mmHg) but not negligible in the 4T1 tumors. A significant change in IFP following radiation was not observed and radiation does not improve the bulk accumulation, intratumoral distribution. In in vivo studies radiation or followed by Doxil resulted in a modest increase in tumor growth delay compared to all other treatments in the 4T1 tumor model. Adapted with permission from [143].