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Pharmacokinetic evaluation of R-VK4-40 following peri-oral administration in rats at 10 mg/kg. (A) Plasma and brain concentration vs time profile of R-VK4-40; data is expressed as mean ± SD, n=3, per time-point. (B) Mean ± SD pharmacokinetic parameters in plasma and brain. Brain to plasma ratio is calculated from mean total AUCbrain to AUCplasma.
