Table 1: In vivo inhibition or overexpression of specific microRNAs supports neuroprotection in the animal models of CNS injury.

Table 1 summarizes the list of regulatory microRNAs and their targets, which, after the experimental intervention using miRNA inhibitors and mimics, support neuronal survival and facilitate recovery in the animal models of CNS injury. The process is mediated via the experimentally verified direct target genes/proteins.

miRNA	Animal model of CNS injury	Treatment	Involved direct miRNA targets
miR-210	Stroke	Overexpression	mBDNF/proBDNF [51]
miR-124	Stroke	Overexpression	Bcl-2 and Bcl-xl [52]; Usp14 [53]
miR-216a	Stroke	Overexpression	JAK2 [54]
miR-29b	Stroke	Overexpression	Aquaporin-4 [55]
miR-29c	Stroke	Overexpression	Birc2 [56]
miR-128–3p	Stroke	Overexpression	p38α [57]
miR-93	Stroke	Overexpression	Nrf2 [58]
miR-223	Stroke	Overexpression	GluR2 and NR2B [59]
miR-378	Stroke	Overexpression	Caspase-3 [60]
miR-181	Stroke	Inhibition	BCL2 and XIAP [61]
miR-181b	Stroke	Inhibition	HSPA5 and UCHL1 [62]
miR-155	Stroke	Inhibition	Rheb [63]
miR-30a	Stroke	Inhibition	HSPA5 [64]
miR-27a	TBI	Overexpression	FoxO3a [50]
miR-144	TBI	Inhibition	ADAM-10 [65]
miR-124	Parkinson’s disease	Overexpression	Bim [66]
miR-7	Parkinson’s disease	Overexpression	α-Synuclein [67]
miR-210	CSI	Overexpression	PTP1B and ephrin-A3 [68]
miR-125b	CSI	Overexpression	Sema4D [69]
miR-486	CSI	Inhibition	NeuroD6 [70]
miR-20a	CSI	Inhibition	Ngn1 [71]