Table 1.
Clinical characteristics of the study groups that underwent pooled-DNA sequencing
| Treatment | N | Males (%) |
Age (years)1 |
Caucasian (%) |
BP vs MDD vs SABP (%) |
Age of onset2 |
Comorbidities (%) |
||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Psychosis | Panic disorder |
Alcohol dependence |
Substance dependence |
PTSD | |||||||
| Citalopram | |||||||||||
| Good responder | 16 | 50.0 | 44 (22-58) | 100.0 | 100 vs 0 vs 0 | 17 (9.0) | 68.8 | 20.0 | 31.1 | 31.3 | 43.8 |
| Poor responder | 51 | 58.8 | 46 (24-67) | 86.3 | 96.1 vs 2 vs 2 | 16 (8.7) | 40.0 | 14.0 | 32.0 | 30.0 | 48.0 |
| Paroxetine | |||||||||||
| Good responder | 26 | 50.0 | 49 (22-70) | 92.3 | 80.7 vs 15.4 vs 3.8 | 19 (11.3) | 52.0 | 19.2 | 38.5 | 34.6 | 15.4 |
| Poor responder | 109 | 69.7 | 47 (20-72) | 93.6 | 97.2 vs 2.8 vs 0 | 18 (10.7) | 46.7 | 14.7 | 42.2 | 39.4 | 27.5 |
| Fluoxetine | |||||||||||
| Good responder | 80 | 47.5** | 45 (20-84) | 96.3 | 80.1 vs 16.3 vs 3.8 | 17 (7.3) | 54.1 | 20.3 | 32.9 | 29.1 | 19.0 |
| Poor responder | 143 | 65.7 | 47 (21-76) | 89.5 | 95.1 vs 4.2 vs 0.7 | 19 (10.2) | 50.0 | 18.3 | 42.3 | 33.1 | 27.5 |
| Sertraline | |||||||||||
| Good responder | 58 | 48.3 | 44 (18-72) | 89.7 | 86.2 vs 10.3 vs 3.4 | 17 (9.3) | 55.4 | 26.3 | 31.6* | 28.1 | 21.2 |
| Poor responder | 111 | 59.5 | 47 (21-68) | 88.3 | 93.7 vs 6.3 vs 0 | 17 (7.9) | 51.8 | 19.8 | 50.5 | 32.4 | 32.4 |
SSRI: Selective serotonin reuptake inhibitors; BP: Bipolar disorder; MDD: Major depressive disorder; SABP: Schizoaffective disorder, bipolar type;
PTSD: Posttraumatic stress disorder
1
Median (range)
2
Mean (standard deviation)
*
P < 0.05,
**
P < 0.01