Table 1.
Summary of formulation compositions of Blank NEs, AMG-NE and their physicochemical properties (mean ± SD; n = 3).
| Formulations | Concentrations (%w/w) |
AMG (%w/w) | Droplet size(a) (nm) | PI | Zeta potential (mV) | pH | EE |
LC |
Phase separation(b) | |
|---|---|---|---|---|---|---|---|---|---|---|
| Mixed oil | Mixed surfactant | (%) | (%) | |||||||
| 5MO-8MS | 5 | 8 | 0 | 183 ± 86 | 0.22 ± 0.03 | -2.4 ± 0.3 | 5.8 ± 0.1 | - | - | Not found |
| 10MO-8MS | 10 | 8 | 0 | 212 ± 124 | 0.34 ± 0.02 | -5.8 ± 0.2 | 5.6 ± 0.1 | - | - | Not found |
| 15MO-8MS | 15 | 8 | 0 | 302 ± 217 | 0.51 ± 0.10 | -7.0 ± 0.2 | 5.6 ± 0.1 | - | - | Not found |
| 10MO-5MS | 10 | 5 | 0 | 231 ± 154 | 0.44 ± 0.04 | -6.2 ± 0.3 | 5.7 ± 0.1 | - | - | Not found |
| 10MO-12MS | 10 | 12 | 0 | 324 ± 246 | 0.58 ± 0.04 | -4.6 ± 0.2 | 5.7 ± 0.1 | - | - | Not found |
| 10MO-8MS-0.2AMG | 10 | 8 | 0.2 | 215 ± 122 | 0.32 ± 0.02 | -6.1 ± 0.2 | 5.7 ± 0.1 | 99.24 ± 0.03 | 1.1 ± 0.00 | Not found |
(a)
Drop size represented the mean of Z-average with SD from particle size distribution histograms.
(b)
Phase separation of NEs that was observed after they were centrifuged at 5,000 rpm for 30 min.