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. Author manuscript; available in PMC: 2020 Jul 1.

Published in final edited form as: Trends Immunol. 2019 Jun 4;40(7):613–634. doi: 10.1016/j.it.2019.04.010

Recruitment in the skin is mediated by CLA, E- and P-Selectin while both integrin-dependent and –independent recruitment can occur (compare Box 2). In the brain microvasculature both selectins (green), PSGL-1 (grey), integrins (dark-green/orange), CXCR2 and ICAM-1 (turquoise) are involved. In the liver, recruitment appears mostly selectin independent through CD44/hyaluronan-dependent-interaction, whereas in postcapillary venules also select independent recruitment can occur. In the kidney, E-selectin has been implicated in neutrophil recruitment in kidney injury models. Within glomerular vessels, immediate arrest occurs without rolling and is mediated by platelet derived P-selectin. The cremaster model was used to demonstrate the classical recruitment cascade implying tether and sling formation. In joints CARD9 was implicated in the recruitment of neutrophils. Both selectin-dependent and – independent recruitment can be observed. The intestine relies on a LTB4-driven, CD11/CD18 dependent extravasation. Microbiome mediated neutrophil recruitment relies on CXCR2. The heart features integrin (LFA-1/Mac-1)-ICAM-1 dependent recruitment. NET release relies on Midkine, LRP1 and PAD4. Recruitment in the lung appears in small capillaries. Both selectin dependent and –independent recruitment can occur. Recruitment depends on CXCR2 and TREM1/3. CXCR2: CXC-motive chemokine receptor; ICAM-1: Intercellular adhesion molecule 1; CD44: Cluster of differentiation 44; MRSA: Methicillin resistant staphylococcus aureus; CXCL: CX-C motif ligand; PAD4: Protein arginine deiminase 4; LFA-1: Lymphocyte function-associated antigen 1; Mac-1: Macrophage-1 antigen; LRP1: Low Density Lipoprotein Receptor-related protein 1; CARD9: Caspase recruitment domain-containing protein 9; C5a: Complement component 5a; LTB4: leukotriene B4; IL-1: Interleukin-1;PSGL-1: P-selectin glycoprotein ligand-1.

Symbols: Bacteria; Neutrophil; Platelets; Megakaryocyte; MRSA; Lung epithelial cell; Endothelial cell; NET; Selectin; PSGL-1; CD44; Hyaluronan; Integrin; ICAM.

Inline graphic — Recruitment in the skin is mediated by CLA, E- and P-Selectin while both integrin-dependent and –independent recruitment can occur (compare Box 2). In the brain microvasculature both selectins (green), PSGL-1 (grey), integrins (dark-green/orange), CXCR2 and ICAM-1 (turquoise) are involved. In the liver, recruitment appears mostly selectin independent through CD44/hyaluronan-dependent-interaction, whereas in postcapillary venules also select independent recruitment can occur. In the kidney, E-selectin has been implicated in neutrophil recruitment in kidney injury models. Within glomerular vessels, immediate arrest occurs without rolling and is mediated by platelet derived P-selectin. The cremaster model was used to demonstrate the classical recruitment cascade implying tether and sling formation. In joints CARD9 was implicated in the recruitment of neutrophils. Both selectin-dependent and – independent recruitment can be observed. The intestine relies on a LTB4-driven, CD11/CD18 dependent extravasation. Microbiome mediated neutrophil recruitment relies on CXCR2. The heart features integrin (LFA-1/Mac-1)-ICAM-1 dependent recruitment. NET release relies on Midkine, LRP1 and PAD4. Recruitment in the lung appears in small capillaries. Both selectin dependent and –independent recruitment can occur. Recruitment depends on CXCR2 and TREM1/3. CXCR2: CXC-motive chemokine receptor; ICAM-1: Intercellular adhesion molecule 1; CD44: Cluster of differentiation 44; MRSA: Methicillin resistant staphylococcus aureus; CXCL: CX-C motif ligand; PAD4: Protein arginine deiminase 4; LFA-1: Lymphocyte function-associated antigen 1; Mac-1: Macrophage-1 antigen; LRP1: Low Density Lipoprotein Receptor-related protein 1; CARD9: Caspase recruitment domain-containing protein 9; C5a: Complement component 5a; LTB4: leukotriene B4; IL-1: Interleukin-1;PSGL-1: P-selectin glycoprotein ligand-1.

Symbols: Bacteria; Neutrophil; Platelets; Megakaryocyte; MRSA; Lung epithelial cell; Endothelial cell; NET; Selectin; PSGL-1; CD44; Hyaluronan; Integrin; ICAM.