Table 2.
Genotype Frequencies of TYMS, GOLGA7, RYR3, and KIAA0423 Polymorphism in Cases and Controls
| Model | Genotype | Control (%) | Case (%) | OR (95% CI) | p Value |
|---|---|---|---|---|---|
| rs11337 HWE: p = 0.51 | |||||
| Co-dominant | GG | 779 (59.9) | 384 (63.5) | 1.00 (reference) | |
| Heterozygote | GT | 460 (35.4) | 194 (32.0) | 0.86 (0.70–1.05) | 0.14 |
| Homozygote | TT | 61 (4.7) | 27 (4.5) | 0.90 (0.56–1.43) | 0.65 |
| Dominant | GG | 779 (59.9) | 384 (63.5) | 1.00 (reference) | 0.14 |
| GT+TT | 521 (40.1) | 221 (36.5) | 0.86 (0.71–1.05) | ||
| Recessive | GG+GT | 1,239 (95.3) | 578 (95.5) | 1.00 (reference) | 0.82 |
| TT | 61 (4.7) | 27 (4.5) | 0.95 (0.60–1.51) | ||
| Overdominant | GG+TT | 840 (64.6) | 411 (68) | 1.00 (reference) | 0.16 |
| GT | 460 (35.4) | 194 (32) | 0.86 (0.7–1.06) | ||
| Allele |
G | 2,018 (77.6) | 962 (79.5) | 1.00 (reference) | 0.19 |
| T | 582 (22.4) | 248 (20.5) | 0.89 (0.76–1.06) | ||
| rs1044129 HWE: p = 0.86 | |||||
| Co-dominant | GG | 259 (19.9) | 106 (17.5) | 1.00 (reference) | |
| Heterozygote | GA | 639 (49.2) | 315 (52.1) | 1.20 (0.93–1.57) | 0.17 |
| Homozygote | AA | 402 (30.9) | 184 (30.4) | 1.12 (0.84–1.49) | 0.44 |
| Dominant | GG | 259 (19.9) | 106 (17.5) | 1.00 (reference) | 0.22 |
| GA+AA | 1,041 (80.1) | 499 (82.5) | 1.17 (0.91–1.50) | ||
| Recessive | GG+GA | 898 (69.1) | 421 (69.6) | 1.00 (reference) | 0.82 |
| AA | 402 (30.9) | 184 (30.4) | 0.98 (0.79–1.20) | ||
| Overdominant | GG+AA | 661 (50.8) | 290 (47.9) | 1.00 (reference) | 0.24 |
| GA | 639 (49.2) | 315 (52.1) | 1.12 (0.93–1.36) | ||
| Allele |
G | 1,157 (44.5) | 527 (43.6) | 1.00 (reference) | 0.58 |
| A | 1,443 (55.5) | 683 (56.4) | 1.04 (0.91–1.19) | ||
| rs1053667 HWE: p = 0.96 | |||||
| Co-dominant | TT | 969 (74.5) | 465 (76.9) | 1.00 (reference) | |
| Heterozygote | CT | 307 (23.6) | 135 (22.3) | 0.92 (0.73–1.15) | 0.46 |
| Homozygote | CC | 24 (1.9) | 5 (0.8) | 0.43 (0.16–1.14) | 0.08 |
| Dominant | TT | 969 (74.5) | 465 (76.9) | 1.00 (reference) | 0.27 |
| CT+CC | 331 (25.5) | 140 (23.1) | 0.88 (0.70–1.10) | ||
| Recessive | TT+CT | 1,276 (98.1) | 600 (99.2) | 1.00 (reference) | 0.09 |
| CC | 24 (1.9) | 5 (0.8) | 0.44 (0.17–1.17) | ||
| Overdominant | TT+CC | 993 (76.4) | 470 (77.7) | 1.00 (reference) | 0.53 |
| CT | 307 (23.6) | 135 (22.3) | 0.93 (0.74–1.17) | ||
| Allele |
T | 2,245 (86.3) | 1,065 (88) | 1.00 (reference) | 0.16 |
| C | 355 (23.7) | 145 (12) | 0.86 (0.70–1.06) | ||
| rs1059394 HWE: p = 0.53 | |||||
| Co-dominant | CC | 131 (10.1) | 80 (13.2) | 1.00 (reference) | |
| Heterozygote | CT | 548 (42.1) | 255 (42.2) | 0.76 (0.56–1.04) | 0.09 |
| Homozygote | TT | 621 (47.8) | 270 (44.6) | 0.71 (0.52–0.97) | 0.03* |
| Dominant | CC | 131 (10.1) | 80 (13.2) | 1.00 (reference) | 0.04* |
| CT+TT | 1,169 (89.9) | 525 (86.8) | 0.74 (0.55–0.99) | ||
| Recessive | CC+CT | 679 (52.2) | 335 (55.4) | 1.00 (reference) | 0.20 |
| TT | 621 (47.8) | 270 (44.6) | 0.88 (0.73–1.07) | ||
| Overdominant | CC+TT | 752 (51.9) | 350 (57.8) | 1.00 (reference) | 1.00 |
| CT | 548 (42.1) | 255 (42.2) | 1.00 (0.82–1.22) | ||
| Allele |
C | 810 (31.2) | 415 (34.5) | 1.00 (reference) | 0.05 |
| T | 1,790 (68.8) | 795 (65.5) | 0.87 (0.75–1.00) | ||
| rs2847153 HWE: p = 0.47 | |||||
| Co-dominant | GG | 534 (41.1) | 223 (36.9) | 1.00 (reference) | |
| Heterozygote | GA | 589 (45.3) | 295 (48.9) | 1.20 (0.97–1.48) | 0.09 |
| Homozygote | AA | 177 (13.6) | 86 (14.2) | 1.16 (0.86–1.57) | 0.32 |
| Dominant | GG | 534 (41.1) | 223 (36.9) | 1.00 (reference) | 0.09 |
| GA+AA | 766 (58.9) | 381 (63.1) | 1.19 (0.98–1.45) | ||
| Recessive | GG+GA | 1,123 (86.4) | 518 (85.8) | 1.00 (reference) | 0.71 |
| AA | 177 (13.6) | 86 (14.2) | 1.05 (0.80–1.39) | ||
| Overdominant | GG+AA | 711 (44.7) | 309 (51.2) | 1.00 (reference) | 0.15 |
| GA | 589 (45.3) | 295 (48.8) | 1.15 (0.95–1.39) | ||
| Allele | G | 1,657 (63.7) | 741 (61.3) | 1.00 (reference) | 0.16 |
| A | 943 (36.3) | 467 (38.7) | 1.11 (0.96–1.28) | ||
HWE, Hardy-Weinberg equilibrium; STR, subtotal resection; NTR, near-total resection; GTR, gross total resection; reference, OR = 1 is the reference compared with other genotypes. *p ≤ 0.05 indicates statistical significance.