Figure 1.

Genetic sub-clones across tumors. Tumor samples were taken before treatment (T) and after treatment (R). Each tumor contained multiple sub-clones and the composition changed after treatment. Genes that previously identified as a commonly mutated genes in colorectal cancer as identified by Giannakis et al. and the most commonly resistant genes identified in our patients were used to label genes present in each sub-clone cluster. Bold and underlined genes are those genes classified as resistant in our patients.