Table 5.
Power to Detect Various Fold Changes in the GMR of the HIV-Specific T Cell Response from Pre- to Post-vaccine (n = 12 Pairs)
| Power | |||
|---|---|---|---|
| GMR | Within-Individual Correlationa | Paired t Test (Approximate) | Wilcoxon Signed Rank Test (exact) |
| 1.3 | 0.7 | 27% | 24% |
| 0.8 | 38% | 49% | |
| 0.9 | 64% | 73% | |
| 1.5 | 0.7 | 54% | 34% |
| 0.8 | 72% | 67% | |
| 0.9 | 95% | 88% | |
| 1.7 | 0.7 | 77% | 59% |
| 0.8 | 91% | 92% | |
| 0.9 | >99% | 99% | |
| 3.0 | 0.5 | 99% | 98% |
Power calculations were based on weekly and monthly CTLA+B data (UNC cohort). A between-individual SD = 0.8 for natural log-transformed CTLA+B was assumed for both pre- and post-vaccine, based on baseline data presented herein.
a
Correlation between pre- and post-vaccination paired measurements.