Figure 4.

Conserved and Cancer-Specific Functions of MutLncs in Pan-Cancer Analysis

(A) The pie chart shows the proportion of MutLncs in different cancer types. The majority of MutLncs are cancer-specific. (B) Distribution of MutLncs identified in more than 7 cancer types. The bar plot represents the p value of MutLncs, and each cancer type is shown as a different color. (C) The matrix shows similarities between pairs of cancer types. The darker green color represents greater similarity between two cancers. Cancer pairs with the same origin and highest similarity are shown. (D) GO terms of MutLncs in LUSC and LUAD. (E) Heatmap showing all enriched KEGG pathways, GO terms, CMAP drugs, and OMIM diseases of MutLncs across cancer types. The darker color represents greater enrichment of MutLncs in these functions. (F) KEGG pathways and GO terms enriched for conserved MutLncs in all cancer types ranked by −log10(P) are presented as bar plots. GO terms and KEGG pathways enriched for MutLncs in STAD ranked by −log10(P) are presented as bar plots.