Figure 6.

MutLncs as Specific Biomarkers of Cancer

(A) Survival analysis of co-occurring MutLnc pairs: Kaplan-Meier survival analysis of two groups of patients with mutation (red line) and without mutation (green line). Survival days are shown along the x axis. Overall survival rates are shown along the y axis. (B) Kaplan-Meier survival analysis of a single MutLnc. (C) MutLnc CACNA1C-AS3 (Ensembl: ENSG00000256769) as an example. Expression profiles of CACNA1C-AS3 in STAD are shown in the right panel. High expression values are depicted in green and low expression in yellow. Co-occurrence status and expression bar plots of CACNA1C-AS3 are shown. (D) Mutation sites and types of CACNA1C-AS3. (E) Secondary structure alterations induced by the mutations. (F) Changes in TF binding sites induced by the mutations.