Table 3.
Correlations between disease activity parameters and serum IL-6, sIL-6R levels, and sIL-6R/IL-6 ratio
| Parameters | Spearman’s coefficients | |||||
|---|---|---|---|---|---|---|
| Serum IL-6 levels | Serum sIL-6R levels | Serum sIL-6R/IL-6 ratio | ||||
| No TCZ (n = 95) | TCZ (n = 69) | No TCZ (n = 95) | TCZ (n = 69) | No TCZ (n = 95) | TCZ (n = 69) | |
| JADAS-27 | 0.65* | 0.38* | 0.30* | –0.14 | –0.56* | –0.49* |
| ESR | 0.66* | –0.08 | 0.05 | –0.64* | –0.64* | –0.34* |
| Active joint counts | 0.44* | 0.33* | 0.22* | –0.06 | –0.38* | –0.32* |
| PGA | 0.65* | 0.38* | 0.32* | –0.05 | –0.56* | –0.44* |
| PtGA | 0.48* | 0.38* | 0.30* | 0.09 | –0.37* | –0.36* |
IL-6 – interleukin 6, JADAS-27 – Juvenile Arthritis Disease Activity Score-27, PGA – physician’s global assessment, PtGA – parent’s or patient’s global assessment, sIL-6R – soluble interleukin 6 receptor, sIL-6R/IL-6 ratio – sIL-6R divided by IL-6, ESR – erythrocyte sedimentation rate
*
p < 0.05