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Metabolite exchange between oligodendrocyte (yellow) and axons (pink) in health and disease. In the healthy CNS, oligodendrocyte-axon coupling allows for bidirectional exchange of metabolites. In multiple sclerosis (MS), damage to myelin, axonal dystrophy, and dying back of oligodendrocytes leads to disrupted oligodendrocyte-axon coupling and impaired metabolite exchange. Figure created in BioRender.
