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Creatine increases mitochondrial density in oligodendrocytes. A significant increase in mitochondria density was calculated in myelin basic protein (MBP)–positive oligodendrocytes after treatment with 100 µM creatine (CR) for 24 hours. Oligodendrocytes treated with PBS or treated with creatine plus guanidinopropionic acid (GPA), a competitive antagonist to the creatine transporter, showed similar mitochondrial density. Modified from Chamberlain and others (2017).
