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. 2018 Aug 20;25(4):334–343. doi: 10.1177/1073858418793077

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Neuronal-derived N-acetylacetate (NAA) promotes myelin synthesis and energy production in oligodendrocytes (yellow). NAA is synthesized in neurons (pink) from acetyl-CoA and aspartate by aspartate N-acetyltransferase (Asp-NAT). In oligodendrocytes, NAA is metabolized by aspartoacylase (ASPA) into acetate and aspartate, which are used for myelin synthesis and energy production via the malate-aspartate shuttle (Mal-Asp shuttle), respectively. Figure created in BioRender.