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. 2018 Oct 15;25(4):344–358. doi: 10.1177/1073858418805002

Figure 2.

Figure 2.

Possible mechanism of seizure induction by photo-activation of interneurons: post-inhibitory rebound spikes. Optogenetic activation of many interneurons (green) hyperpolarizes a large population of pyramidal neurons (black). When the photo-stimulation ends, pyramidal neurons are simultaneously released from inhibition and fire rebound action potentials initiating an ictal discharge.