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. Author manuscript; available in PMC: 2019 Sep 16.
Published in final edited form as: J Med Chem. 2019 Mar 14;62(14):6469–6481. doi: 10.1021/acs.jmedchem.9b00101

Figure 1.

Figure 1.

The proteasome degradation system. Structured proteins with polyubiquitin tags are degraded by the 26S proteasome in an ATP dependent manner (left). Partially unfolded, intrinsically disordered, and oxidatively damaged proteins are directly degraded by the 26S, free 20S, or 20S capped by non-ATPase caps such as PA28 and PA200, without the need for polyubiquitination (right).