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. 2019 Sep 3;93(10):e1021–e1030. doi: 10.1212/WNL.0000000000008066

Figure 4. Age-dependent changes of intracranial volume (ICV), cerebellum, and cerebrum for CAG ≤50.

Figure 4

(A) Age-dependent change of ICV was comparable between groups but differed between male and female participants, F4,113 = 11.06, p = 1.82 × 10−7. The volume difference between male and female participants was significantly larger in the gene-expanded (GE) group than the gene-nonexpanded (GNE) group (GE vs GNE sex difference = 78.9 mL, SE = 31.5 mL, t [121] = 2.51, p = 0.0135). (B) The groups did not differ significantly in age-related change of the cerebellum. The difference in cerebellum volume between male and female participants was significantly larger in the GE group than the GNE group (GE vs GNE sex difference = 7.72 mL, SE = 3.08 mL, t [137] = 2.51, p = 0.0134). (C) The sex-dependent volume difference was also significantly greater in GE than in GNE for the cerebrum (difference = 61.37 mL, SE = 24.90, t [127] = 2.46, p = 0.0115. In addition, age-dependent decline of the cerebrum was significantly faster in the GE group than the GNE group (−3.33 mL/y, SE = 0.94, t [119] = −3.54, p = 0.0006).