Table 4.
Silver staining of sections from the central nervous system of heterozygous mice transgenic for human mutant A53T α-synuclein (tgM83+/−) following intracerebral injection of cerebellar homogenates from cases of multiple system atrophy (MSA) and substantia nigra homogenates from cases of Parkinson’s disease (PD). Sagittal brain sections encompassed brainstem, hippocampus and cerebral cortex. Spinal cord sections were of the lumbar region
| Mouse | Human brain extract | Gallyas silver | Campbell-Switzer silver |
|---|---|---|---|
| tgM83 +/+ | – | – | + |
| tgM83 +/− | – | – | – |
| tgM83 +/− | (1) MSA-P | – | + |
| tgM83 +/− | (2) MSA-P | – | + |
| tgM83 +/− | (3) MSA-P | – | + |
| tgM83 +/− | (4) MSA-P | – | + |
| tgM83 +/− | (5) MSA-P | – | + |
| tgM83 +/− | (6) MSA-C | – | + |
| tgM83 +/− | (7) MSA-C | – | + |
| tgM83 +/− | (1) PD | – | + |
| tgM83 +/− | (2) PD | – | + |
| tgM83 +/− | (3) PD | – | + |
| tgM83 +/− | (4) PD | – | + |
| tgM83 +/− | (5) PD | – | + |