Table 1.

List of FDA-approved viscosupplementation formulations

Brand	Medication	Dosing Regimen	Drug Cost per Injection, a $	Drug Cost per Treatment, $	Total Cost (Drug + Procedure) per Treatment, b $
Durolane	Hyaluronic acid 60 mg per 3 mL	Single injection	N/A	N/A	N/A
Euflexxa	Sodium hyaluronate 20 mg per 2 mL	3 weekly injections	141.79	425.37	569.01
Gel-One	Hyaluronate 30 mg per 3 mL	Single injection	537.36	537.36	585.25
Gelsyn-3	16.8 mg per 2 mL	3 weekly injections	N/A	N/A	N/A
Genvisc 850	Sodium hyaluronate 25 mg per 2.5 mL	5 weekly injections	N/A	N/A	N/A
Hyalgan	Sodium hyaluronate 20 mg per 2 mL	3-5 weekly injections	85.30	255.90 (3) 426.5 (5)	399.54 (3) 665.90 (5)
Hymovis	Hyaluronan 24 mg per 3 mL	2 weekly injections	N/A	N/A	N/A
Monovisc	Hyaluronan 88 mg per 4 mL	Single injection	779.35	779.35	827.23
Orthovisc	Hyaluronan 30 mg per 2 mL	3 weekly injections	147.79	443.37	587.01
Supartz FX	25 mg per 2.5 mL	3 weekly injections	85.30	255.90	399.54
Synvisc	Hylan G-F 20 16 mg per 2.25 mL	3 weekly injections	189.22	567.66	711.30
Synvisc-One	Hylan G-F 20 48 mg per 6 mL	Single injection	567.66	567.66	615.54

FDA, Food and Drug Administration; N/A, not applicable.

^aAccording to Centers for Medicare & Medicaid Services October 2018 Average Sales Price Pricing File (updated September 12, 2018).

^bAccounting for $47.88 charge for Current Procedural Terminology code 20610, “Drain/inj joint/bursa w/o us” performed in a national payment amount for a procedure performed in a facility according to Centers for Medicare & Medicaid Services 2018 Physician Fee Schedule Search.