Table 2.
Genotype of the investigated cytokine gene polymorphisms in AML patients and healthy controls
| SNP | Control group (n1 = 406) | AML group (n2 = 226) | COR (95% CI) | P a | AOR (95% CI) | P b |
|---|---|---|---|---|---|---|
| TGF‐β1 rs1800470 | ||||||
| Additive model | n (%) c | n (%) d | ||||
| GG | 50 (12.3) | 16 (7.1) | Ref. | Ref. | ||
| GA | 165 (40.6) | 135 (59.7) | 2.56 (1.39‐4.69) | .002 | 2.53 (1.38‐4.65) | .003 |
| AA | 191 (47.0) | 75 (33.2) | 1.23 (0.66‐2.29) | .520 | 1.20 (0.65‐2.26) | .550 |
| Dominant model | ||||||
| AA | 50 (12.3) | 16 (7.1) | Ref. | Ref. | ||
| GA + AA | 356 (87.7) | 210 (92.9) | 1.84 (1.02‐3.32) | .042 | 1.82 (1.01‐3.29) | .046 |
| IFN‐γ rs2430561 | ||||||
| Additive model | ||||||
| TT | 67 (16.5) | 54 (23.9) | Ref. | Ref. | ||
| TA | 215 (53.0) | 105 (46.5) | 0.61 (0.40‐0.93) | .022 | 0.61 (0.40‐0.94) | .024 |
| AA | 124 (30.5) | 67 (29.6) | 0.67 (0.42‐1.07) | .092 | 0.67 (0.42‐1.07) | .092 |
| Dominant model | ||||||
| TT | 67 (16.5) | 54 (23.9) | Ref. | Ref. | ||
| TA + AA | 339 (83.5) | 172 (76.1) | 0.63 (0.42‐0.94) | .024 | 0.63 (0.42‐0.95) | .026 |
| TNF‐α rs361525 | ||||||
| Additive model | ||||||
| GG | 389 (95.8) | 211 (93.4) | Ref. | Ref. | ||
| GA | 17 (4.2) | 15 (6.6) | 1.63 (0.77‐3.32) | .182 | 1.09 (0.79‐1.52) | .207 |
| TNF‐α rs1800629 | ||||||
| Additive model | ||||||
| GG | 271 (66.7) | 148 (65.5) | Ref. | Ref. | Ref. | |
| GA | 127 (31.3) | 73 (32.3) | 1.05 (0.74‐1.50) | .775 | 1.05 (0.74‐1.49) | .778 |
| AA | 8 (2.0) | 5 (2.2) | 1.14 (0.37‐3.56) | .816 | 1.14 (0.38‐3.74) | .756 |
| Dominant model | ||||||
| GG | 271 (66.7) | 148 (65.5) | Ref. | Ref. | ||
| GA + AA | 135 (33.3) | 78 (34.5) | 1.06 (0.75‐1.49) | .748 | 1.06 (0.75‐1.50) | .739 |
| TNF‐α rs1800750 | ||||||
| GG | 402 (100.0) | 220 (97.3) | Ref. | .002 | Ref. | Ref. |
| GA | 0 (0.0) | 6 (2.7) | ND | ND | ND | |
| IL‐6 rs1800795 | ||||||
| CC | 68 (16.7) | 32 (14.2) | Ref. | Ref. | ||
| CG | 188 (46.3) | 127 (56.2) | 1.44 (0.89‐2.31) | .137 | 1.43 (0.89‐2.30) | .143 |
| GG | 150 (36.9) | 67 (29.6) | 0.95 (0.57‐1.58) | .841 | 0.93 (0.56‐1.55) | .782 |
| CG + GG | 338 (83.3) | 194 (85.8) | 1.22 (0.77‐1.92) | .393 | 1.21 (0.79‐1.52) | .417 |
| IL‐10 rs1800872 | ||||||
| GG | 222 (54.7) | 117 (51.8) | Ref. | Ref. | Ref. | |
| GT | 158 (38.9) | 99 (43.8) | 1.19 (0.85‐1.67) | .314 | 1.21 (0.86‐1.70) | .271 |
| TT | 26 (6.4) | 10 (4.4) | 0.73 (0.34‐1.57) | .418 | 0.73 (0.34‐1.56) | .410 |
| GT + TT | 184 (45.3) | 109 (48.2) | 1.12 (0.81‐1.56) | .482 | 1.14 (0.82‐1.58) | .435 |
| IL‐10 rs1800896 | ||||||
| TT | 144 (35.5) | 74 (32.7) | Ref. | Ref. | Ref. | |
| TC | 188 (46.3) | 109 (48.2) | 1.13 (0.78‐1.63) | .519 | 1.12 (0.77‐1.61) | .560 |
| CC | 74 (18.2) | 43 (19.0) | 1.13 (0.71‐1.81) | .607 | 1.11 (0.69‐1.77) | .677 |
| TC + CC | 262 (64.5) | 152 (67.3) | 1.13 (0.80‐1.59) | .490 | 1.11 (0.79‐1.57) | .545 |
Abbreviations: AOR, adjusted odd ratio for age and gender; CI, confidence interval; COR, crude odd ratio.
a
P‐value obtained from Chi‐square test, Fisher's Exact test or univariate binomial logistic regression.
b
P‐value obtained from multivariable logistic model.
c
Percentages were calculated for genotypes relative to the number of controls.
d
Percentages were calculated for genotypes relative to the number of cases.
Bold values denoted statistically significant results (P < 0.05).