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. 2018 Feb 5;2(1):e29. doi: 10.1097/HS9.0000000000000029

Figure 1.

Figure 1

Biological data during the clinical course of the patient. BCR-ABL1 fusion transcript ratio was of 36.9% at diagnosis of CML while CALR allele burden was of 0.8% and was only detectable using digital PCR. At 3 months, BCR-ABL1 ratio decreased to 0.96% and CALR mutation allele burden increase to 27%. During the follow up, CML achieved a BCR-ABL1 molecular response MR4 at 1 year and MR4.5 at 15 months. The CALR mutation remained stable between 20% and 30% of allele burden.