Figure 2.

Examples of ZEB expression switching as molecular drivers of important cell fate decisions during hematopoietic differentiation. (A) Counter oscillating expression levels of Zeb1 and Zeb2 during T-cell differentiation with indications of known differentiation defects in Zeb1 and Zeb2 loss-of-function mouse models. (B) Oscillating Zeb2 expression levels during dendritic cell (DC) differentiation with indications of known differentiation defects in Zeb2 loss-of-function mouse models. CD4 = T-cell CD4⁺ single positive, CD8 = T-cell CD8⁺ single positive, cDC1 = conventional DC subtype 1, cDC2 = conventional DC subtype 2, CDP = common dendritic cell progenitor, CLP = common lymphoid progenitor, CMP = common myeloid progenitor, DN = T-cell CD4⁻CD8⁻ double negatives, DP = T-cell CD4⁺CD8⁺ double positives, GMP = granulocyte monocyte progenitor, HSC = hematopoietic stem cell, MDP macrophage/DC progenitor, MPP = multipotent progenitor, pDC = plasmacytoid DC.