Figure 4.

ZEB2 is cancer dependency factor in various hematopoietic and leukemia/lymphoma cell lines. Scatter plot Dependency versus Expression. This figure is based on data available via https://depmap.org/rnai/genedeps?gene=ZEB2,⁹⁰ filtered on “hematopoietic and lymphoid.” Dependency for ZEB2 was determined in a genome-scale loss-of-function study in diverse cancer cell lines. DEMETER is an analytical that segregates on- from off-target effects of RNAi. This figure clearly depicts that large proportion of the analyzed leukemia cell lines do express ZEB2 and are dependent on it, with negative ZEB2 DEMETER z-score. RPKM = reads per kilobase per million mapped reads.