Figure 1.

Hematological parameters of Jak2^V617F mice treated with the LSD1 inhibitor IMG-7289. Peripheral blood was obtained by retrobulbar puncture and analyzed on an Advia 120 system at the indicated time points (n = 8 mice per group). Mean and standard error of mean are shown. (A) White blood cell (WBC) count, (B) platelet counts, (C) absolute neutrophil count (ANC), (D) absolute monocyte count, (E) hematocrit (HCT), and (F) absolute reticulocyte count. Statistical analysis was conducted using Student t tests. ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001, ^∗∗∗∗P < 0.0001 versus vehicle-treated mice.