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Timeline of regulatory approval of major drugs for treatment of CLL paralleled by improving survival of CLL patients. Survival data are from a Danish population-based study150 and drug approval dates are taken from the website of the FDA. Chlorambucil and cyclophosphamide, which were introduced in the 1950s, are omitted from the diagram for space reasons. CLL = chronic lymphocytic leukemia, FDA = Food and Drug Administration.
