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. 2019 Jul 23;10(9):1314–1321. doi: 10.1021/acsmedchemlett.9b00270

Figure 2.

Figure 2

(A) Left and right panel, cell viability of FaDu or SCC-25 with log doses (−9.3 to −4.3) of SU093 in the absence or presence IR. (B) Left and right panels, cell viability assay of HSNCC FaDu and SCC-25, respectively, cells were treated with different doses of radiation (2.5 or 5 Gy) with or without SU093 (1 μM). On day 7 of post-treatment, viable cells were quantified using the MTT reagent, and absorbance was read at 570 nm. Cell viability was calculated by normalizing the response of each condition to the control (absence of radiation and SU093). (C,D) Colony formation assay of FaDu and SCC-25 with SU093 with or without 5 Gy of ionizing radiation. Control group received vehicle only. (E) Colony formation quantification of FaDu and SCC-25 with SU093 or combined (5 Gy) treatment. Asterisks indicate t test comparison between each treatment and control, where ***P < 0.001, **P < 0.01, *P < 0.05.