Table 1. Systematically Minimizing Binding to M109 in p38α.
compound | X | Y | p38α Kd (nM)a |
---|---|---|---|
4 | N | NH | 2.2 ± 0.63 |
6 | N | O | 120 ± 51 |
7 | CH | NH | 6500 ± 6300 |
8 | CH | O | 5000 ± 6100 |
Kd values were determined by KINOMEscan. Data represents the mean and standard error from two independent trials.