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. 2019 Aug 2;10(9):1296–1301. doi: 10.1021/acsmedchemlett.9b00227

Table 1. Systematically Minimizing Binding to M109 in p38α.

graphic file with name ml9b00227_0005.jpg

compound X Y p38α Kd (nM)a
4 N NH 2.2 ± 0.63
6 N O 120 ± 51
7 CH NH 6500 ± 6300
8 CH O 5000 ± 6100
a

Kd values were determined by KINOMEscan. Data represents the mean and standard error from two independent trials.