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| compound | N atom location | BRD4-D1 IC50 (μM)a |
|---|---|---|
| 22 | 1,2 | 9.7 ± 1.8 |
| 23 | none | 12 ± 1.1 |
| 5 | 1 | 3.6 ± 0.05 |
| 24 | 2 | 97 ± 2.6 |
| 25 | 3 | >100 |
| 26 | 4 | >100 |
IC50 values were determined by fluorescence anisotropy. Data represents the mean and standard deviation of three independent trials.
