Table 1. Impact of 3-Indole Substitution on Potencya.
Relative % bound at 10 μM of compound at 0.02, 0.2, 2, and 20 h.
Observed rate (kobs/[I] M–1 s–1) derived from 0.02, 0.2, 2, and 20 h of relative % bound at 10 μM compound.
Dose response GDP-KRASG12C/C118A (1–169) SOS1-catalyzed GTP exchange assay.
Quantification of phospho-ERK1/2 following compound treatment and EGF stimulation by MSD assay in MIA PaCa-2 cells. For number of replicates, mean, and standard deviations, see the Supporting Information.