Table 3.

Univariate analyses of variables in osteosarcoma patients aged over 40 using Kaplan-Meier method

Variable	Primary			Secondary
	OS (Log-rank p value)	CSS (Log-rank p value)		OS (Log-rank p value)
Age (≤60 vs>60)	<0.001	<0.001		<0.001
Gender	0.013	0.007		0.750
Decade of diagnosis	<0.001	<0.001		0.200
≥2000sa vs1970s	<0.001	<0.001		—
≥2000sa vs 1980s	0.002	<0.001		—
≥2000sa vs 1990s	0.791	0.058		—
1990s vs 1970s	0.006	<0.001		—
1990s vs 1980s	0.050	0.004		—
1980s vs 1970s	0.224	0.004		—
Race	0.757	0.430		0.396
Location	<0.001	<0.001		<0.001
Axial vs Appendicular	<0.001	<0.001		<0.001
Axial vs Other locations	<0.001	<0.001		0.001
Appendicular vs Other locations	0.938	0.861		0.408
Tumor gradeb (Low vs High)	<0.001	<0.001		0.001
Tumor stage	<0.001	<0.001		<0.001
Distant vs Localized	<0.001	<0.001		<0.001
Distant vs Regional	<0.001	<0.001		<0.001
Regional vs Localized	<0.001	<0.001		0.252
Tumor size	<0.001	<0.001		<0.001
>10cm vs <5cm	<0.001	<0.001		<0.001
>10cm vs 5-10cm	<0.001	<0.001		0.001
5-10cm vs <5cm	0.001	0.003		0.235
Surgery	<0.001	<0.001		<0.001
Radiation treatment	<0.001	<0.001		0.022
Chemotherapy	0.581	0.742		0.002