Table 3.
Mean methylation and standard deviation according to the histological status and methylation site, grouped according to HPV region.
| Region | Site | Normal (N=7) | CIN1 (N=23) | CIN2 (N=45) | CIN3 (N=61) | SCC (N=6) | AdenoCa (N=3) |
|---|---|---|---|---|---|---|---|
| 5'UTR | 7270 | 11.1±11.8 | 12.4±14.9 | 14.0±10.0 | 14.7±10.2 | 20.0±20.6 | 28.0±17.0 |
| 7461 | 3.7±2.3 | 2.6±1.3 | 2.7±1.1 | 4.3±2.5 | 12.0±10.1 | 10.0±9.5 | |
| 7455 | 4.2±0.9 | 3.1±1.4 | 3.4±1.1 | 4.1±4.2 | 14.2±16.0 | 11.3±9.0 | |
| 7428 | 3.2±1.2 | 2.9±1.6 | 3.1±1.6 | 3.4±1.5 | 11.0±8.6 | 9.0±6.5 | |
| Mean | 5.6±3.4 | 5.3±4.0 | 5.8±2.5 | 6.6±3.3 | 13.3±13.1 | 14.5±8.3 | |
| Enhancer | 7535 | 9.4±5.5 | 8.1±6.1 | 6.3±3.2 | 11.1±8.4 | 27.6±14.1 | 21.3±10.0 |
| 7553 | 11.1±9.5 | 12.0±9.1 | 10.1±5.5 | 14.6±11.2 | 39.2±19.2 | 21.3±5.0 | |
| Mean | 10.2±7.2 | 10.10±7.4 | 8.2±4.1 | 12.9±9.0 | 33.4±17.3 | 21.3±7.5 | |
| Promoter | 7862 | 2.8±0.9 | 2.4±1.2 | 1.7±0.6 | 1.7±0.8 | 3.1±1.7 | 3.6±2.0 |
| 31 | 1.4±0.5 | 2.2±1.0 | 2.3±1.7 | 1.8±1.3 | 7.5±9.9 | 9.0±11.3 | |
| 37 | 2.8±1.5 | 2.3±1.2 | 3.0±1.6 | 2.6±1.9 | 6.8±9.2 | 9.0±10.4 | |
| 43 | 2.0±1.0 | 2.3±1.1 | 2.2±3.6 | 1.4±1.2 | 2.6±3.2 | 9.3±12.7 | |
| 52 | 2.4±1.5 | 1.8±0.9 | 2.2±1.5 | 1.9±1.4 | 7.0±9.2 | 9.6±13.2 | |
| 58 | 2.8±2.4 | 2.3±1.2 | 2.4±1.7 | 2.2±1.5 | 7.0±10.3 | 9.6±11.5 | |
| Mean | 2.4±1.0 | 2.2±0.7 | 2.3±1.3 | 1.9±1.0 | 5.6±6.8 | 8.3±10.2 | |
| E6 | 494 | 8.4±7.5 | 8.3±6.9 | 8.8±7.8 | 10.2±8.3 | 25.3±16.1 | 12.6±12.4 |
| 502 | 12.0±11.9 | 13.7±12.0 | 14.3±13.5 | 16.2±12.3 | 40.6±27.8 | 18.0±14.0 | |
| 506 | 8.0±6.9 | 8.1±6.7 | 8.2±7.9 | 9.2±8.2 | 25.3±17.1 | 11.0±11.3 | |
| Mean | 9.4±8.7 | 10.0±8.4 | 10.4±9.6 | 11.9±9.5 | 30.4±20.1 | 13.8±12.5 | |
| E7 | 765 | 10.0±4.8 | 8.0±3.9 | 10.3±6.9 | 10.2±6.8 | 29.6±17.2 | 4.5±2.1 |
| 780 | 5.0±2.4 | 5.3±3.1 | 5.3±2.9 | 5.5±4.1 | 23.6±11.3 | 4.5±2.1 | |
| 790 | 3.6±1.8 | 5.6±3.9 | 5.0±3.0 | 6.2±5.3 | 24.0±13.3 | 3.0±0.0 | |
| Mean | 6.2±2.7 | 6.3±3.4 | 6.9±3.9 | 7.3±5.0 | 25.7±13.7 | 4.0±0.0 |