Table 4.
Performance characteristics for discriminating CIN3+ cases using two cut-offs, one that maximizes overall accuracy (Optimal threshold) and one that balances sensitivity vs. specificity (Balanced threshold).
| Site 7535 | Site 7553 | |||
|---|---|---|---|---|
| Optimal threshold | Balanced threshold | Optimal threshold | Balanced threshold | |
| Sensitivity | 68.1 | 68.1 | 75.3 | 60.8 |
| Specificity | 66.2 | 66.2 | 54.9 | 69.0 |
| PPV | 66.2 | 66.2 | 61.9 | 65.6 |
| NPV | 68.1 | 68.1 | 69.6 | 64.4 |
| FPR | 33.8 | 33.8 | 45.0 | 30.9 |
| FNR | 31.8 | 31.8 | 24.6 | 39.1 |
| OA | 67.1 | 67.1 | 65.0 | 65.0 |
| OR | 4.1 | 4.1 | 3.7 | 3.4 |
PPV: Positive Predictive Value, NPV: Negative Predictive Value, FPR: False Positive Rate, FNR: False Negative Rate, OA: Overall Accuracy, OR: Odds Ratio. Note that Optimal threshold and balanced threshold was the same for site 7535 while for site 7553 the optimal threshold resulted in high sensitivity at the cost of specificity.