Table 4.

Comparison of tumor recurrence survival in stage II-III CRC patients stratified by different risk scores in prognostic models combining TNM stage, postoperative CA72-4 and postoperative CTCs or combining postoperative CA72-4 and postoperative CTCs analyzed by univariate and multivariate Cox proportional hazard regression.

Parameters	Univariate analysis							Multivariate analysis
	B	Wald	P-value	HR	95.0% CI			B	Wald	P-value	HR	95.0% CI
Prognostic score 1 (TNM+CA72-4+CTCs)
Binary classification
High risk vs. Low risk	1.774	13.442	<0.001	5.894	2.283	15.213
Multiple classification		10.765	0.005
Moderate risk vs. Low risk	1.918	3.267	0.071	6.810	0.851	54.517
High risk vs. Low risk	2.998	8.090	0.004	20.053	2.540	158.304
Prognostic score 2 (CA72-4+CTCs)
Binary classification
High risk vs. Low risk	1.837	10.492	0.001	6.279	2.066	19.083		1.807	10.146	0.001	6.092	2.004	18.521
Multiple classification		13.458	0.001						13.035	0.001
Moderate risk vs. Low risk	1.692	8.381	0.004	5.429	1.727	17.069		1.666	8.133	0.004	5.289	1.684	16.616
High risk vs. Low risk	2.669	12.116	<0.001	14.427	3.210	64.847		2.647	11.725	0.001	14.111	3.101	64.201

Abbreviations: CRC, colorectal cancer; CTCs, circulating tumor cells; CA72-4, carbohydrate antigen 72-4; HR, hazard ratio; CI, confidence interval. Note, Bold, indicates the association was significant; Italic, indicates a trend of association (0.5≤P<0.1).