Table 3:

Association of Treatment Intervention by 90 Day Visit with KCCQ Change

	KCCQ Change [1]
Change in Treatment	Difference in Means (95% CI) [2]	P-value	Adjusted Difference in Means (95% CI) [3,4]	P-value
Change in Any Treatment	4.12 (2.58, 5.66)	<.001	3.01 (1.43, 4.60)	<.001
Beta Blocker	5.15 (2.89, 7.41)	<.001	4.27 (1.95, 6.59)	<.001
ACEI/ARB	5.04 (2.59, 7.49)	<.001	4.06 (1.57, 6.56)	0.001
Aldosterone	4.50 (1.42, 7.57)	0.004	3.77 (0.63, 6.90)	0.018
ARNI	2.46 (−0.38, 5.29)	0.089	1.52 (−1.32, 4.35)	0.294
Diuretic	7.46 (4.80, 10.12)	<.001	5.43 (2.68, 8.18)	<.001

^[1]KCCQ Change is defined as KCCQ Score at 90 days - KCCQ Score at baseline.

^[2]Unadjusted analysis is based occurrence of a change in treatment (Yes vs. No) using a hierarchical linear model adjusting for site.

^[3]Adjusted analysis is based on the occurrence of a change in treatment (Yes vs. No), age, gender, race, Hispanic ethnicity, employment status, insurance provider, highest level of education, total household income, body mass index, systolic blood pressure, heart rate, left ventricle ejection fraction (%), atrial fibrillation, chronic obstructive pulmonary disease, coronary artery disease, depression, diabetes mellitus, hypertension, hyperlipidemia, smoking status, ventricular tachycardia/ventricular/fibrillation, chronic renal insufficiency, heart failure hospitalization in the prior 12 months, cardiac resynchronization therapy, and NYHA classification using a hierarchical linear model adjusting for site.

^[4]Missing covariate data was imputed using a full conditional specification method taking into account the joint distribution of other variables.

Abbreviations: ACEI = angiotensin converting enzyme inhibitor, ARB = angiotensin II receptor blocker, ARNI = angiotensin receptor-neprilysin inhibitors