Table 1.
Top 20 differentially expressed transcription factors in En/pNC and KEn/pNC
| Gene ID | Symbol | Log2FC (En/pNC) |
q-value | Gene ID | Name | Log2FC (KEn/pNC) |
q-value |
|---|---|---|---|---|---|---|---|
| Upregulated | Upregulated | ||||||
| 101750712 | ZNF750 | 9.86 | 2E-18 | 100857422 | POU3F4 | 8.77 | 1E-121 |
| 418669 | SHOX | 8.22 | 2E-224 | 100858556 | DMRT2 | 7.09 | 2E-135 |
| 396546 | HMX1 | 8.03 | 2E-19 | 426886 | TWIST3 | 6.69 | 5E-142 |
| 396346 | SOHO-1 | 7.85 | 5E-20 | 418669 | SHOX | 6.67 | 5E-128 |
| 100858556 | DMRT2 | 7.59 | 3E-160 | 101748749 | ZNF469 | 6.12 | 6E-108 |
| 419863 | IRF6 | 6.99 | 2E-30 | 101750712 | ZNF750 | 5.46 | 7E-05 |
| 395943 | PAX6 | 6.69 | 4E-14 | 107051987 | POU3F3 | 5.29 | 3E-36 |
| 100857422 | POU3F4 | 5.65 | 2E-58 | 396158 | MYBL1 | 5.28 | 2E-226 |
| 424652 | GLIS1 | 5.34 | 1E-167 | 395405 | TWIST2 | 5.12 | 0 |
| 777244 | SHOX2 | 5.30 | 1E-91 | 396346 | SOHO-1 | 4.86 | 1E-08 |
| 395714 | BARX2 | 4.69 | 9E-19 | 423315 | NPAS3 | 4.56 | 2E-156 |
| 101748749 | ZNF469 | 4.66 | 3E-71 | 777244 | SHOX2 | 4.34 | 2E-58 |
| 395590 | DLX3 | 4.53 | 6E-19 | 373990 | TBX2 | 4.10 | 1E-240 |
| 421416 | FOSL2 | 4.45 | 6E-61 | 768789 | FOXE1 | 4.08 | 1E-43 |
| 374101 | SCX | 4.05 | 2E-194 | 100859610 | CREB3L1 | 3.86 | 2E-120 |
| 429506 | GRHL2 | 3.98 | 3E-22 | 396210 | NFIA | 3.79 | 3E-159 |
| 373990 | TBX2 | 3.97 | 8E-228 | 419631 | TFAP2E | 3.61 | 3E-82 |
| 428651 | GRHL1 | 3.71 | 3E-41 | 395713 | TFAP2B | 3.50 | 2E-240 |
| 423923 | EMX2 | 3.64 | 9E-114 | 427171 | PIK3R1 | 3.44 | 3E-113 |
| 419631 | TFAP2E | 3.42 | 1E-74 | 374101 | SCX | 3.41 | 1E-139 |
| Downregulated | Downregulated | ||||||
| 418313 | TBX15 | −10.53 | 7E-38 | 418313 | TBX15 | −10.53 | 2E-41 |
| 373932 | NKX3–2 | −8.69 | 6E-65 | 107053847 | DLX2 | −10.44 | 5E-65 |
| 396383 | ISL1 | −7.84 | 2E-15 | 428534 | SOX17 | −10.25 | 4E-37 |
| 396391 | GATA5 | −7.35 | 8E-12 | 419106 | GATA3 | −9.68 | 6E-123 |
| 396129 | SIM1 | −7.33 | 2E-30 | 724086 | SIX2 | −9.55 | 3E-137 |
| 396109 | FOXD1 | −7.00 | 2E-119 | 428021 | ZIC2 | −9.30 | 4E-94 |
| 419106 | GATA3 | −6.89 | 2E-100 | 395573 | SOX10 | −8.93 | 5E-147 |
| 503512 | FOXL2 | −6.75 | 1E-90 | 396109 | FOXD1 | −8.18 | 1E-138 |
| 395752 | NKX6–1 | −6.60 | 9E-50 | 395191 | OTX2 | −7.86 | 2E-19 |
| 395176 | EBF2 | −6.12 | 5E-72 | 395633 | MYF5 | −7.81 | 4E-16 |
| 395794 | FOXD3 | −5.98 | 3E-49 | 395794 | FOXD3 | −7.69 | 1E-61 |
| 374137 | MEOX2 | −5.93 | 2E-36 | 421786 | LIN28B | −7.65 | 0 |
| 374127 | PAX3 | −5.74 | 2E-81 | 374127 | PAX3 | −7.46 | 7E-103 |
| 107053847 | DLX2 | −5.68 | 3E-47 | 503512 | FOXL2 | −7.46 | 4E-102 |
| 395795 | FOXD2 | −5.57 | 5E-133 | 396391 | GATA5 | −7.35 | 1E-13 |
| 419388 | PRDM16 | −5.56 | 7E-155 | 395752 | NKX6–1 | −7.19 | 5E-57 |
| 100857760 | FOXF2 | −5.54 | 5E-100 | 395596 | EPAS1 | −7.05 | 8E-174 |
| 395961 | NR5A2 | −5.42 | 5E-25 | 373932 | NKX3–2 | −6.98 | 8E-67 |
| 724086 | SIX2 | −5.35 | 4E-94 | 395977 | GFI1B | −6.97 | 1E-25 |
| 428021 | ZIC2 | −4.68 | 4E-57 | 374137 | MEOX2 | −6.93 | 8E-44 |
Bold values indicate differentially expressed genes between the two groups (abs(log2)≥1 and q < 0.05). Minus signs indicate downregulation. The individual TPM and standard deviations for the RNAseq replicates are listed in Supplementary Table 7.