Table 2.
Among ProtecT cases and controls, odds of prostate cancer for top metabolites1
| Name | OR | LCI | UCI | P-value2 |
|---|---|---|---|---|
| Lipids and Lipoprotein Subclass Characteristics | ||||
| Small HDL (particle concentration) | 1.102 | 1.042 | 1.167 | 0.00070 |
| VLDL (mean particle diameter) | 0.906 | 0.856 | 0.958 | 0.00056 |
| Cholesterol Esters (CE) | ||||
| CE in medium LDL | 1.105 | 1.044 | 1.170 | 0.00058 |
| CE to total lipids ratio in medium LDL | 1.108 | 1.044 | 1.180 | 0.00062 |
| CE in small HDL | 1.135 | 1.071 | 1.205 | 0.00002 |
| CE to total lipids ratio in small HDL | 1.100 | 1.038 | 1.167 | 0.00111 |
| CE in small LDL | 1.099 | 1.039 | 1.165 | 0.00107 |
| CE to total lipids ratio in small LDL | 1.100 | 1.037 | 1.169 | 0.00139 |
| Free (FC) & Total Cholesterol (TC) | ||||
| FC in IDL | 1.105 | 1.044 | 1.170 | 0.00057 |
| FC in large LDL | 1.101 | 1.041 | 1.166 | 0.00080 |
| FC in medium HDL | 1.109 | 1.045 | 1.179 | 0.00060 |
| FC to total lipids ratio in medium HDL | 1.109 | 1.045 | 1.179 | 0.00055 |
| TC in HDL3 | 1.098 | 1.038 | 1.162 | 0.00109 |
| TC in medium LDL | 1.100 | 1.039 | 1.164 | 0.00095 |
| TC to total lipids ratio in medium LDL | 1.100 | 1.039 | 1.167 | 0.00105 |
| TC in small HDL | 1.144 | 1.080 | 1.213 | <0.00001 |
| TC to total lipids ratio in small HDL | 1.099 | 1.039 | 1.165 | 0.00106 |
| TC in small LDL | 1.097 | 1.037 | 1.161 | 0.00132 |
| TC to total lipids ratio in small LDL | 1.100 | 1.039 | 1.166 | 0.00107 |
| TC to total lipids ratio in small VLDL | 1.099 | 1.038 | 1.163 | 0.00105 |
| Phospholipids (PL) & Total Lipids (TL) | ||||
| PL in IDL | 1.100 | 1.040 | 1.164 | 0.00092 |
| PL to total lipids ratio in medium LDL | 0.904 | 0.853 | 0.957 | 0.00046 |
| PL to total lipids ratio in medium VLDL | 1.145 | 1.082 | 1.211 | <0.00001 |
| PL in very small VLDL | 1.099 | 1.039 | 1.163 | 0.00103 |
| PL to total lipids ratio in very small VLDL | 1.120 | 1.056 | 1.190 | 0.00013 |
| TL in small HDL | 1.108 | 1.048 | 1.173 | 0.00035 |
| Triglycerides (TG) | ||||
| TG to total lipids ratio in medium VLDL | 0.907 | 0.857 | 0.959 | 0.00064 |
| TG to total lipids ratio in small VLDL | 0.906 | 0.856 | 0.958 | 0.00055 |
| Fatty Acids (FA) | ||||
| Ratio of omega-6 FA to total FA | 1.102 | 1.041 | 1.166 | 0.00080 |
| Ratio of saturated FA to total FA | 0.890 | 0.841 | 0.942 | 0.00006 |
| Amino Acids | ||||
| Isoleucine | 0.893 | 0.844 | 0.944 | 0.00008 |
| Leucine | 0.901 | 0.851 | 0.953 | 0.00027 |
| Tyrosine | 0.886 | 0.837 | 0.937 | 0.00003 |
| Valine | 0.913 | 0.863 | 0.965 | 0.00139 |
| Fluid Balance | ||||
| Albumin | 1.104 | 1.043 | 1.168 | 0.00065 |
ProtecT=Prostate Testing for Cancer and Treatment trial; OR=odds ratio; LCI=lower limit of 95% confidence interval; UCI=upper limit of 95% confidence interval; HDL= high-density lipoprotein; LDL=low-density lipoprotein; VLDL=very low-density lipoprotein; IDL=intermediate-density lipoprotein.
1
Models adjusted for age, centre, and imputed family history of prostate cancer (imputed because family history was only available for 90% of subjects).
2
P-value threshold corrected for multiple testing (P<0.05/37=0.0014).