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. Author manuscript; available in PMC: 2019 Sep 16.
Published in final edited form as: Nat Med. 2019 May 29;25(6):1001–1011. doi: 10.1038/s41591-019-0465-8

Extended Data Fig. 4 ∣. Longitudinal changes in microbiome profiles across trimesters during pregnancy.

Extended Data Fig. 4 ∣

a, Vaginal microbiome profiles of 41 pregnant women of African (n = 22) or non-African (n = 19) ancestry who provided at least 1 sample from each of 3 trimesters. b, Alpha diversity measures of richness (species counts) and evenness (Shannon index) of samples from a. Diversity measures calculated using the vegan package (see Methods). Box plots were generated in R using standard approaches. The bar represents the median and the boxes indicate interquartile ranges. Asterisks indicate statistical significance (*P < 0.05; **P < 0.01). c, L1-Norm PCA analysis (see Methods) of samples from a. Legends are indicated. n-Afr, women of non-African ancestry; Afr: women of African ancestry. See Supplementary Table 5 for sequence read statistics for data presented in this figure.