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. 2019 Sep 6;10:2074. doi: 10.3389/fimmu.2019.02074

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Copyright © 2019 Paalme, Rump, Mädo, Teras, Truumees, Aitai, Ratas, Bourge, Chiang, Ghalali, Tordjmann, Teras, Boudinot, Kanellopoulos and Rüütel Boudinot.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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P2X4 expression in several mouse brain tumors is mainly intracellular. Gating strategy of staining of mouse astrocytoma (ALT; A), glioma (GL261; D); and microglial cell line (BV2; G). The percentage of gated cells are indicated. Membrane staining was determined by FACS for mouse astrocytoma (ALT; B); glioma (GL261; E) and microglial cells (BV2; H) with anti-hP2X4 mAb27. Intracellular staining were also analyzed, respectively in mouse astrocytoma (ALT; C), glioma (GL261; F) and microglial cell line (BV2; I). Note that astrocytoma and glioma show surface staining, while microglial cell line has P2X4 receptors only expressed in intracellular compartments (I).