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. 2019 Sep 16;2019(9):CD013120. doi: 10.1002/14651858.CD013120.pub2

Gomez‐Jimenez 1993.

Methods Open randomised clinical trial
Participants Country: Spain
Number randomised: 60
Post‐randomisation dropouts: not stated
Revised sample size: 60
Average age: 59 years
Females: 13 (21.7%)
Presence of other features of decompensation (hepatorenal syndrome, hepatic encephalopathy, or variceal bleeding): not stated
Alcohol‐related cirrhosis: both
Viral‐related cirrhosis: not stated
Autoimmune disease‐related cirrhosis (e.g. PSC, PBC, AIH): not stated
Other causes for cirrhosis: both
Treated for ascites in addition to antibiotics (for example albumin or diuretics): not stated
Follow‐up in months: 0.5
Years of recruitment: 1987‐1990
Exclusion criteria

  • History of allergy to beta‐lactam antibiotics

  • Haemorrhage into ascites

  • Pancreatitis

  • Tuberculous peritonitis

  • Peritoneal carcinomatosis
Interventions Participants were randomly assigned to two groups.
 Group 1: cefonicid (n = 30)
 Further details: cefonicid 2g IV twice/day for 10 or 4 days after becoming afebrile, whichever was shortest.
 Group 2: ceftriaxone (n = 30)
 Further details: ceftriaxone 2g IV once/day for 10 or 4 days after becoming afebrile, whichever was shortest.
Outcomes Outcomes reported

  • Mortality

  • Any adverse event (number of people)

  • Proportion with recovery from SBP
Notes We were unable to locate the current contact details of the author.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Comment: this information was not available.
Allocation concealment (selection bias) Unclear risk Comment: this information was not available.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Comment: open clinical trial
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Comment: open clinical trial
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Comment: this information was not available.
Selective reporting (reporting bias) Low risk Comment: a prepublished protocol was not available but the authors report routinely measured clinical outcomes adequately.
Other bias Low risk Comment: no other bias was noted.