Table 1.

The table is divided into two sections. In the upper section, some of the most important lnc-RNAs collected in the literature appear up-regulated in oral squamous cell carcinomas as well as their main biological effects. In the lower section are those that are down-regulated in the tumours mentioned above.

Up-regulated NC-RNAs	Function
Up-regulated NC-RNAs
MALAT1	EMT-mediated cell migration and invasion via regulating N-cadherin, Vimentin and E-cadherin104,105.
PANDAR	Promoter of CDKN1A antisense DNA damage activated RNA106.
TUC338	Enhances proliferation and reduced apoptosis107.
lincRNA-ROR	Acts as a sponge for miRNA-145-5p to modulate c-Myc, Kl, Sox2, and Oct4 genes106.
POU3F3	Regulates cell proliferation, and apoptosis106.
FTH1P3	Acts as a molecular sponge for miRNA-224 to modulate frizzled 5 Expression108.
UCA1	Promotes tumour invasion and metastasis possibly through WNT/β-catenin pathway109.
CCAT1	Acts as a sponge for miRNA-155-5p and let7b-5p. May be a predictor for poor treatment response106.
LINC00152	Correlated with cancer progression, advanced stage, cancer relapse, and invasion110.
AC132217.4	Promotes cell migration and EMT via IGF2 levels111.
MIR31HG	HIF-1α co-activator112.
LINC00668	Acts as CeRNA for miRNA-297 to regulate VEGFA regulation113.
Inc-sox5	Regulates apoptosis and cell cycle114.
LNC00673	Promotes tumour invasion and metastasis115.
miR-8485	Promotes the proliferation, migration and invasion of tumour cells116.
miR‑382‑5p	Induce cell migration and invasion. CAF‑OSCC communication vehicle117.
Down-regulated NC-RNAs
miR-145-5p	Pro-apoptosis related miRNA118.
NKILA	Inhibits the phosphorylation of IKβα NF-kβ, and inhibits EMT119.
MEG3	Regulates cell proliferation, cell cycle and apoptosis. Therapeutic target for OSCC120–122.
miR-101-3p	Regulates cell proliferation by COL10A1 gene91.
miR-3188	Contributes to the malignant phenotypes of HNC cells through the derepression of BCL2100.