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. 2019 Sep 10;8(1):1324–1336. doi: 10.1080/22221751.2019.1663131

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Cytokine response in the lungs of H7 SGR and SPM virus infected mice. Cytokine levels were detected in lung homogenates upon infection with SC35-HA_SC35F (black), SC35-HA_111T (bright grey), SC35-HA_146S (grey), SC35-HA_340R (dark grey) on days 3 and 6 p.i.. (A) Expression levels of the CC-chemokine ligand 2 (CCL2, MCP-1), (B) CCL5 (RANTES), (C) CCL12 (MCP-5), (D) TNF receptor superfamily member 1A (TNFRSF1A), (E) colony-stimulating factor CSF2 (GM-CSF), (F) CSF3 (GCSF), (G) IL-4, (H) IL-9 and (I) IL-12 were measured in lung homogenates of infected BALB/c mice (n = 3). The relative expression levels were calculated in relation to the positive control set to 100%.