Table 2:
Results for three-point bending and μCT analyses performed on femurs from 8 week old Cthrc1 null mice (Cthrc1tm1Vli) and corresponding wildtype mice (WT) on the C57BL/6J background are shown. Data are means ± SD.
| Males | Females | |||
|---|---|---|---|---|
| WT (n=6) | Cthrc1tm1Vli (n=6) | WT (n=6) | Cthrc1tm1Vli (n=6) | |
| Three-point bending data | ||||
| Max. Moment (N-mm) | 30.15±4.49 | 21.38±3.40** | 23.29±1.87 | 20.30±3.12 |
| Bending stiffness (N-mm2) | 838±142 | 566±159** | 744±131 | 641±115 |
| Estimated Modulus (GPa) | 6.43±1.25 | 6.19±1.42 | 8.33±1.58 | 7.71±0.64 |
| Mid-diaphysis μCT data | ||||
| Femur length (mm) | 14.55±0.20 | 13.75±0.20** | 13.84±0.61 | 13.62±0.40 |
| Ct.Th (mm) | 0.161±0.011 | 0.123±0.006** | 0.132±0.012 | 0.121±0.013 |
| Ct.TMD (mgHA/cm3) | 1030±8 | 1014±6** | 1012±18 | 1040±14 |
| Ct.Ar (mm2) | 0.774±0.114 | 0.555±0.037** | 0.574±0.042 | 0.518±0.061 |
| Ma.Ar (mm2) | 1.201±0.125 | 1.208±0.058 | 1.103±0.069 | 1.125±0.023 |
| Tt.Ar (mm2) | 1.975±0.238 | 1.763±0.088* | 1.677±0.059 | 1.644±0.066 |
| Ct.Ar/Tt.Ar (%) | 39.10±1.29 | 31.48±1.07** | 34.26±2.70 | 31.47±2.55 |
| Ct. Porosity (%) | 0.442±0.166 | 0.613±0.088* | 0.518±0.138 | 0.500±0.034 |
| pMOI (mm4) | 0.424±0.111 | 0.279±0.030** | 0.267±0.020 | 0.239±0.033 |
| Imax (mm4) | 0.289±0.078 | 0.187±0.021** | 0.177±0.014 | 0.156±0.020 |
| Imin (mm4) | 0.135±0.034 | 0.092±0.010** | 0.090±0.009 | 0.083±0.013 |
*
Denotes statistically significant with p<0.05;
**
denotes statistically significant with p<0.01.