TABLE 1.

Hospital-based uses for oral and intravenous PPI therapies

Conditions requiring antisecretory therapy	Route of administration	References
Patients with established need for PPI therapy who cannot take oral medication	Oral to IV, IV to oral	Hartmann25
GERD	Oral to IV, IV to oral	Bocheneck,18 Fumagalli,27 Metz,26 Wurzer,56 Plein63
Hypersecretory disorders (e.g. ZES)	Oral to IV, IV to oral	Simon,58 Pisegna,11 Vinayek,59 Metz28
Conditions affecting drug absorption*	Oral to IV, IV to oral	Gubbins41
Management of peptic ulcers and gastrointestinal bleeding	Oral to IV, IV to oral, IV	Brunner,31 Labenz,30 Lind,29 Brunner52
Stress ulcer prophylaxis	IV	Otani62
Gastric outlet obstruction	IV	Brunner52
Acid aspiration syndrome prophylaxis	IV	Cruickshank,32 Rocke33
Diagnostic test for patients with NCCP†	IV	Fass55

^*Patients with chronic nausea and vomiting or severe diarrhea, such as those receiving chemotherapy.

^†Based on results of an oral PPI study.

IV indicates intravenous; and NCCP, noncardiac chest pain.