Mettl21c is required for proper muscle function.
A and B, relative body weight (A) and SOL muscle weight (B) of HET and KO mice. C, myofiber numbers in SOL muscles of HET and KO mice. D, myofiber size in SOL muscles of HET and KO mice. E, immunostaining of Myh7 (red) and Myh2 (green) in SOL muscles of HET or KO mice. Scale bar: 500 μm. F, quantification of different types of myofibers in SOL muscles of HET or KO mice. G, running speed and distance of HET and KO mice in treadmill test. Error bars represent mean + S.D. of seven mice. * indicates p < 0.05 (Student's t test).