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. 2019 Jul 26;294(37):13606–13618. doi: 10.1074/jbc.RA119.009713

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© 2019 Shen et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 7. — Pathogenicity analysis of TGEV and TGEV(91–95sg). A, piglets were inoculated with the viruses. The average weight gain of the piglets was recorded on the day of death or euthanasia as the final time point. In the TGEV group, one piglet died by the 3rd day, and the other piglets died by the 4th day. In the TGEV(91–95sg) and mock groups, the piglets were euthanized on the 8th day. Data are represented as mean ± S.D., n = 3–5. B, clinical mental state scores of the piglets in the different groups. The following criteria were used for evaluation: 0, normal; 1, mild lethargy (slow to move; head down); 2, moderate lethargy (stands but tends to lie down); 3, heavier lethargy (lies down; occasionally stands); and 4, severe lethargy (recumbent; moribund). Data are represented as mean ± S.D., n = 3–5. C, survival rates of the piglets in each group. Survival curves for the piglets infected with the recovered viruses in each group are shown. D, gross lesions in piglets inoculated with the recombinant viruses. The intestinal lesions were examined on the day of death or after euthanasia at the final time points. The necropsy images show transparent intestines observed in piglets inoculated with TGEV and TGEV(91–95sg) but not in mock-inoculated piglets. E, histopathological examination of the intestines from the recombinant TGEV-infected piglets. Different segments, including the duodenum, jejunum, ileum, large intestine, and stomach, were taken from each group and then processed for H&E staining. Representative images are shown. Original magnification × 100 (scale bars 200 μm).