Table 5.

Areas of Greater Increases and Decreases in Blood Flow with Stress Challenge in CAD Patients with Depression without (N=8) Compared to those with (N=5) Stress Induced Myocardial Ischemia

Increased Blood Flow						Decreased Blood Flow
Z Score*	Voxel Number**	Talairach Coordinates				Z Score*	Voxel Number**	Talairach Coordinates
		x	y	z	Brain Region			x	y	z	Brain Region
4.18	303	10	−32	42	Posterior Cingulate (31)	3.42	382	−18	−52	42	L. Precuneus (7)
3.99	1039	36	−12	12	R. Sup Temporal Gyrus(22)/Insula	2.93		−14	−56	72
3.58		60	8	−2	R. Sup Temporal Gyrus(22)	2.73		−26	−46	50
3.43		58	12	−10	R. Sup Temporal Gyrus (12,38)	3.32	304	34	30	24	R. Middle Frontal Gyrus (46,9)
3.99	785	−58	14	−8	L. Sup Temporal Gyrus (12,38)	3.10		26	16	34
3.61		−54	−8	8	L. Sup Temporal Gyrus (22)	2.79		34	24	30
3.13		−50	−12	−2	L. Sup Temporal Gyrus (22)	3.25	272	40	−50	40	R. Inf. Parietal Lobule (40)
3.17	132	−66	−18	−6	L. Middle Temporal Gyrus (21)	2.96		−8	−48	38	L. Precuneus (7)
2.51		−66	−12	0		2.94		−4	−54	26	L. Precuneus (7)
2.96	260	46	46	−12	R. Middle Frontal Gyrus (11)	3.03	179	−6	−74	44	R. Precuneus (7)
2.91		54	34	−14		2.73		−30	−68	40	Visual Association Ctx (19)
2.81		44	44	−2		2.61		4	−60	36
2.86	63	−20	−72	−16	Cerebellum	2.91	67.00	38	−32	80	Precentral/Postcentral (1,2,3,4
2.77	53	0	34	26	Caudal Anterior Cingulate (32)
2.71	83	−10	−36	−18	Midbrain/PAG
2.77	44	2	38	−16	Orbitofrontal (11)

^*Z Score>2.67, p<.005

^**Number of voxels within the activated cluster

Areas in bold represent the voxel with greatest activation in a contingent group of voxels; non-bold areas are other areas of activation within the same group